1. Ibutamoren (MK-677, L-163,191) acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin.

2. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels.

3. MK-677 is currently under development as a potential treatment for reduced levels of these hormones which make it a promising therapy for the treatment of frailty in the elderly.

4. MK-677 also alters metabolism of body fat and so may have application in the treatment of obesity

5. Mk-677 is an orally administrated growth hor secretagogue originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete growth hor

6. MK-677 could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn't require any injections nor does it have any side effects like GHRP-6.

7. This GHS (Growth Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.